Saturday, October 11, 2008
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Friday, October 3, 2008
USANA Announces Dismissal Of Lawsuit, Johnson V. USANA
Michigan Dental Association Stops Illegal Practice Of Dentistry, Safeguards Public
Cardinal Health Inc., Agrees To Pay $34 Million To Settle Claims That It Failed To Report Suspicious Sales Of Widely-Abused Controlled Substance
Thursday, October 2, 2008
Med sci monit 2008; 14(10):br205-209 "sildenafil citrate on the inducibility of ventricular fibrillation and upper limit of vulnerability in swine"
Material/Methods: Twenty-one pigs (25–30 kg) were randomly assigned into 3 groups of 7 pigs each. A solution containing 100 mg (group 100) or 50 mg (group 50) sildenafil citrate or 100 cc saline (group control) was infused intravenously in each pig. A train of 10 S1s was delivered from an RV electrode, and an S2 stimulus was delivered at the peak of the T wave of the last S1 activation to determine the VFT and ULV, before and after drug administration.
Results: The 100 mg sildenafil citrate significantly (P<0.03) decreased VFT, accounting for ~36% by peak voltage and ~52% by total energy, and significantly (P<0.009) increased ULV, accounting for ~28% by peak voltage, and ~56% by total energy.
Conclusions: Supratherapeutic concentrations of sildenafil citrate significantly decreased the VFT and increased the ULV, resulting in an expansion of the VF induction window during the vulnerable period. (Source: Medical Science Monitor)
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S.D. Supreme Court Hears Case On Whether Identity Of Donor To Abortion Ban Initiative Should Be Revealed
New Jersey Court Hears Arguments Over Legality Of Bush Administration SCHIP Directive Limiting Enrollment
New Book Offers Proposals For Dealing With Juveniles Who Commit Crime
Wednesday, October 1, 2008
Knife Wounds Guidance 'timely And Appropriate', Sayd Medical Defence Union Of Scotland
UK Out In The Cold On Insurance Question Says Medical Defence Union
Tuesday, September 30, 2008
Massachusetts Attorney General Martha Coakley's Office Recovers Over 3.5 pounds Million For Massachusetts Medicaid Program
UK Travellers Warned About Fake Malaria Drugs - Malaria Awareness Campaign, Organised By GSK Travel Health
Monday, September 29, 2008
Wall Street Journal Examines How No-Pregnancy Orders Reflect Previous Forced-Sterilization Projects
HIV/AIDS Services Agency Sues New Hampshire Town For Restricting Access To Group Home
President Bush Signs Legislation To Expand Protections Under Americans With Disabilities Act
James W. Saxton Guest Presenter At National Bariatric Summit
Saturday, September 27, 2008
Impact Of CSI-Style Programming On Jurors: How Attitudes And Expectations May Impact On Jurors' Decision-Making In A Courtroom
Friday, September 26, 2008
Lawsuit Filed In 2002 Alleged Surgeons Received Improper Incentives From Medtronic To Prescribe Products
Thursday, September 25, 2008
Advocates At U.N. Meeting Protest Jailing Of Iranian Physicians
AG Mukasey Rejects Immigration Board's Denial Of Malian Woman's Asylum Claim Over Genital Cutting
HDMA Commends House Passage Of Legislation To Combat Illegal Online Sales Of Prescription Medicines
Wednesday, September 24, 2008
Florida Medicaid Beneficiaries Sue State To Receive Home-Based Care
AHF Calls On Iran To Release Two Respected AIDS Physicians Held Since June
The Doctors Company Hosts Third Annual Legal Summit To Provide Industry's Best Claims Defense For Physicians
Tuesday, September 23, 2008
Sublingual application of liquid nitrendipine does not result in critical hypotension in healthy volunteers under phosphodiesterase-5 inhibition.
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Sublingual application of liquid nitrendipine does not result in critical hypotension in healthy volunteers under phosphodiesterase-5 inhibition.
Clin Hemorheol Microcirc. 2008;39(1-4):323-8
Authors: Park JW, Leithäuser B, Jung F
INTRODUCTION: The introduction of phosphodiesterase-5 inhibitors as sildenafil, tadalafil, or vardenafil, has tremendously improved the treatment of erectile dysfunction. Patients with the common comorbidity of cardiovascular disease and erectile dysfunction, however, are at risk for critical hypotension in case of self-treatment of cardiac angina with nitrates after the intake of a phosphodiesterase-5 inhibitor. METHODS: We evaluated the safety of 5 mg sublingual nitrendipine after pre-treatment of 8 healthy male volunteers (42.1+/-9.6 yrs) with 20 mg tadalafil. Randomly four different protocols were compared using six hours blood pressure recordings: (1) baseline, (2) 20 mg tadalafil, (3) 5 mg nitrendipine, and (4) 20 mg tadalafil+5 mg nitrendipine. RESULTS: The blood pressure was not significantly affected by tadalafil. Nitrendipine lowered the systolic blood pressure significantly by -1.91 mmHg (p=0.0079). The co-medication of 20 mg tadalafil+5 mg nitrendipine lowered the blood pressure significantly by -2.86 mmHg (p<0.0001). There was no statistically significant difference between tadalafil and nitrendipine (p=0.598). Relevant hypotension (systolic blood pressure of <85 mmHg) was observed in none of the study individuals during the four protocols. CONCLUSIONS: Sublingual nitrendipine seems to be safe for self-treatment of an anginal attack in patients with stable coronary artery disease, who have taken a phosphodiesterase-5 inhibitor. However, our findings on hemodynamic changes in apparently healthy volunteers have to be confirmed in patients with coronary artery disease.
PMID: 18503141 [PubMed - indexed for MEDLINE]
(Source: Clinical Hemorheology and Microcirculation)
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Sublingual application of liquid nitrendipine does not result in critical hypotension in healthy volunteers under phosphodiesterase-5 inhibition.
| Related Articles |
Sublingual application of liquid nitrendipine does not result in critical hypotension in healthy volunteers under phosphodiesterase-5 inhibition.
Clin Hemorheol Microcirc. 2008;39(1-4):323-8
Authors: Park JW, Leithäuser B, Jung F
INTRODUCTION: The introduction of phosphodiesterase-5 inhibitors as sildenafil, tadalafil, or vardenafil, has tremendously improved the treatment of erectile dysfunction. Patients with the common comorbidity of cardiovascular disease and erectile dysfunction, however, are at risk for critical hypotension in case of self-treatment of cardiac angina with nitrates after the intake of a phosphodiesterase-5 inhibitor. METHODS: We evaluated the safety of 5 mg sublingual nitrendipine after pre-treatment of 8 healthy male volunteers (42.1+/-9.6 yrs) with 20 mg tadalafil. Randomly four different protocols were compared using six hours blood pressure recordings: (1) baseline, (2) 20 mg tadalafil, (3) 5 mg nitrendipine, and (4) 20 mg tadalafil+5 mg nitrendipine. RESULTS: The blood pressure was not significantly affected by tadalafil. Nitrendipine lowered the systolic blood pressure significantly by -1.91 mmHg (p=0.0079). The co-medication of 20 mg tadalafil+5 mg nitrendipine lowered the blood pressure significantly by -2.86 mmHg (p<0.0001). There was no statistically significant difference between tadalafil and nitrendipine (p=0.598). Relevant hypotension (systolic blood pressure of <85 mmHg) was observed in none of the study individuals during the four protocols. CONCLUSIONS: Sublingual nitrendipine seems to be safe for self-treatment of an anginal attack in patients with stable coronary artery disease, who have taken a phosphodiesterase-5 inhibitor. However, our findings on hemodynamic changes in apparently healthy volunteers have to be confirmed in patients with coronary artery disease.
PMID: 18503141 [PubMed - indexed for MEDLINE]
(Source: Clinical Hemorheology and Microcirculation)
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Editorial Examines How McCain, Obama Picks For Supreme Court Would Differ
Monday, September 22, 2008
Supreme Court Prepares To Hear Pre-Emption Case That Could Give Pharmaceutical Companies Protection Against Liability
Saturday, September 20, 2008
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Friday, September 19, 2008
Pennsylvania Physicians Concerned About Renewal Of Medical Malpractice Insurance Subsidy Program
Imprisoned Cuban Physician, Guatemalan Forensic Scientist Wins NYAS Human Rights Award
Confusion Over Purpose Of Falls Clinics Compromises Effectiveness Of Service, UK
Edinburgh Nurse Suspended From Practice By Regulator, UK
Thursday, September 18, 2008
Kansas Abortion Provider Tiller Files For Dismissal Of Charges
Abbott Uses NAFTA To Charge Mexico Significantly Higher Than Middle-income Country Rate
Medical Defence Union Continues 'Doctors For Doctors' Tradition With New Chief Executive, UK
Tuesday, September 16, 2008
Sleep apnea may spur erectile dysfunction
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Federal Court Panel Grants Appeal For Woman Denied Asylum For Seeking To Avoid Forced Sterilization In China
Dental Lasers - Leading Manufacturer Defends Itself Against NLT's Claims; Seeks Permanent Injunction, USA
Monday, September 15, 2008
Limiting Resident Surgeon's Work Hours Associated With Fewer Complications For Patients Having Gallbladder Surgery
Senate Approves Bill To Expand Protections Under Americans With Disabilities Act
Depuy Spine And Biedermann Motech Resolve Patent Litigation With Allez Spine
Illinois Hospital Appeals Tax Exemption Case To State Supreme Court
Statement Of Colleen Connell, American Civil Liberties Union, Illinois, Re: Appellate Court Decision In Miller V. American Fertility Services
Saturday, September 13, 2008
Sleep apnea may spur erectile dysfunction
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Friday, September 12, 2008
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USA Today Examines Practice Of Billing Rape Survivors For Medical Exams In Wasilla While Palin Was Mayor
Wednesday, September 10, 2008
Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study
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Massachusetts' Proposed Rule Could Lead To Federal Lawsuit, Partners HealthCare Warns
Boston Globe Examines Imprisonment Of Two HIV/AIDS Physicians, Brothers In Iran
Conservative Advocates Successfully Lobby For Language On High Court Nominees In GOP Platform, The Hill Reports
Fathers Need Their Children
Tuesday, September 9, 2008
British Columbia Appeal Court Upholds Provincial 'Bubble Zone' Law On Abortion Protests
Supreme Court To Consider Whether To Bar Liability Lawsuits Against Pharmaceutical Companies
Major Presidential Candidates Discuss Proposals For Health Care, Other Issues At AARP Convention
Nurse Who Used Someone Else's Passport To Get Job Cautioned By Regulator
Hopeful Medical Industry News On Malpractice Premiums For Physicians Is Released For 2008
Saturday, September 6, 2008
Spectranetics Announces Federal Investigation, USA
Friday, September 5, 2008
The Doctors Company Files For Rate Decrease For California Physicians
Studies Examine Effects Of Medicare Coverage Policies On Service Utilization, Primary Care Delivery Systems For Low-Income People
Kane County, Ill., Judge Throws Out Parts Of Defamation Lawsuit Against Planned Parenthood Of Illinois
Thursday, September 4, 2008
Table of contents
Large-scale questionnaire survey of erectile dysfunction drugs in japanese men
Health Affairs Web Exclusive Examines Supreme Court Decision About ERISA Conflict Of Interest
Large-scale questionnaire survey of erectile dysfunction drugs in japanese men